If you haven't heard of them, Miracle Berries (or miracle fruit) are a bit of a nifty food. Rather than being faster than a speeding bullet or able to cure cancer, their miracle is the ability to turn sour foods sweet. In North America, they're not incredibly popular but you can find them online (I got a pack from Amazon) in tablet form. Most of the research on them seems to come from Japan, where they're being tested as a sweetener/additive suitable for diabetics and cancer patients undergoing chemotherapy. They're also used by foodies and neuroscience students as a "flavour-tripping" experience.
The plant is called Synsepalum dulcificum, and it's native to West Africa, where it's chewed before meals. Its disarming ability to alter the taste of food is due to a glycoprotein (a protein with saccharides stuck on to it) named miraculin, which was named either really creatively or not creatively at all. The pulp from these fruits contains this weird glycoprotein, and is freeze-dried and sold as tablets.
But to understand how miracle berries can alter our sense of taste, a quick explanation (maybe not super quick) as to what normally happens when we taste food:
Food enters the mouth and we chew it up (or we should, if we listen to our mothers). Tastants (molecules we perceive as flavours) are released from the food- these are sensed by taste buds present in our tongues and in a band across the top of our mouths.
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| This picture isn't to scale, unless you have a serious problem. |
There are a bunch of things that contribute to how we perceive the flavour of food like smell, temperature, viscosity and whatnot, but for the sake of this post we'll be concerned with how tastants alter our taste buds.
As we all know from elementary school, there are four basic tastes: sweet, sour, bitter, and salty. While not entirely true (there are more, but these four are universally accepted), they're the best understood. They're grouped into first class (sour and salty) and second class (bitter and sweet) based on how they work.
Sour:
What we perceive as sourness is really acidity. Generally, acids aren't great for you (eroding your teeth, melting your skin off and making you a supervillain, etc.) but in small doses, they're pretty tasty. Think sour candy or pickles. Acidity in our food comes from hydrogen ions. They're tiny, positively charged, and either floating around free in our food or break off from a larger molecule within the cells in our mouths. These ions accumulating in our Type III taste receptor cells causes a signal to shuttle up through the cranial nerves into the brainstem.
Salty:
Saltiness in our foods comes predominantly from sodium (in sodium chloride, which is table salt). Sodium, when separated from chloride, is a positively charged ion that can enter cells through pores that selectively allow it to enter. Like sour tastes, saltiness is sensed by Type III taste buds, and enters the brain in a similar fashion.
Sweet:
A little more complex than sourness or saltiness, sweetness in our diet mostly comes from sugars. The sweet receptors are composed of two different molecules stuck together, and the resulting chain protrudes from the cell membrane of Type II taste receptor cells. This is important because sugar molecules are much larger than ions and can't enter the cell. The sweet receptors, when activated on the outside of the cell, trigger a cascade of events within the cell that results in the transduction of a signal. The signal then proceeds as with sour and salty tastes.
Bitter:
Bitter foods get their characteristic gross taste from a variety of molecules, although they seem to share a similar off-putting note. Like in sweet taste receptors, bitter taste receptors aren't a pore through which a molecule enters, but rather a switch that triggers events within a cell. There are some variations in the ability to sense bitter foods, and some theories to explain them, but the take-home message is that many different compounds can generate a bitter taste, and they're generally sensed the same way sweet ones are.
After the sensations are picked up by our taste receptor cells, the signal is carried through cranial nerves (in this case, the facial, glossopharyngeal and vagus) through the medulla. The medulla is a fairly basic brainstem structure with a host of regulating functions, and it serves as a relay centre for these nerves. It then passes through the thalamus, which is sort of a switchboard operator, but for your senses. Sensory information related to sound, taste, and pressure all go through the thalamus, then gets sent off to other regions.
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| Fortunately, biology-based disciplines no longer require artistic skill. The placement might be a bit off- as it turns out, drawing is hard. |
In the case of taste processing, the insula (or gustatory cortex) receives thalamic input, which then continues on to the orbitofrontal cortex. The neurons in these regions are suggested to integrate sensory stimuli from different modalities like touch and smell, and contribute to how we experience our food.
Miraculin alters the way we perceive sourness. By itself, it doesn't really taste like much (it isn't sweet at all) but at a low pH (i.e. in an acidic environment) it produces a sweet taste. In recent years, this effect has been shown to be a result of its binding to sweet receptors. At a neutral pH, miraculin doesn't really have an effect, but at a low pH, it acts as an agonist (causes the sweet receptors to be more active).
For this experiment (this is an incredibly poorly designed experiment, but apparently it's science if you write it down), I recruited three friends to help me out. They opted to use code names- not to protect their identities, but because they thought it'd be funny.
The Panel:
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| Hector Cunningham. Part Irish. Part Scottish. Part beard. |
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| Chet Manley. Watch out, ladies. |
| Randy. One word, like Cher. |
The Food:
| Lemons, raspberries, aged cheddar, jalapeño peppers, garlic dill pickles, apples, grapefruit, apple cider vinegar, orange juice, tequila. Not pictured: yellow mustard and sour cream. |
Some highlights before taking the miracle berries:
Lemons: super sour.
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| Randy has a laissez-faire attitude towards dental health. |
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| If his eyes were open, you'd be able to see the regret in them. |
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| The grapefruit was juicy, I guess. |
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| Who even likes grapefruit, Randy? |
| YOU get a poor life decision! YOU get a poor life decision! EVERYBODY gets a poor life decision! |
| The winner is: alcoholism! |
Apple cider vinegar shots are a terrible idea.
| Nobody trusted me after the tequila shots. |
| In this photo: Heartburn. So much heartburn. |
What we learned with the miracle berries:
Lemons taste like candy!
| Randy: blurry and loving life |
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| Pictured: the face of regret. |
| We'd hoped that the miracle berries would make tequila taste better. We were disappointed. |
If you take shots of apple cider and tequila, you may vomit.
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| We both had a significant amount of heartburn. Fortunately, no one ended up vomiting. |
Our observations:
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| Somehow, my tables are even worse than my drawings. |
Further reading:
Human sweet taste receptor mediates acid-induced sweetness of miraculin. Kozumi et al., 2011 (PNAS)
Differential sweetness of commercial sour liquids elicited by miracle fruit in healthy young adults. Igarashi et al., 2013 (Food Sci Tech Int)
Sensation & Perception (Wolfe, Kluender, Levi, 2012)






































